HE Research Fellows
Medical and Life Sciences
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Yunlong CaoPeking UniversityResearch Interests
Development of Long-Acting Neutralizing Antibody Nasal Spray for Respiratory Viruses
Significance
To develop a broad-spectrum neutralizing antibody formulation capable of prolonged retention on the nasal mucosa for the long lasting prevention of respiratory viral infections.
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Yupei ChenSun Yat-sen UniversityResearch Interests
Innovations and Applications in the Metastatic Mechanisms and Precision Treatment Strategies for Nasopharyngeal Carcinoma
Significance
Our findings are like equipping the diagnosis and treatment of nasopharyngeal carcinoma with a “navigation system”: they not only enable more precise identification of patients at high risk of metastasis, but also reveal novel therapeutic targets. Going forward, we will further optimize strategies to enhance efficacy and reduce toxicity in nasopharyngeal carcinoma treatment based on molecular subtyping, artificial intelligence, and other cutting-edge technologies.
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Qi DouThe Chinese University of Hong KongResearch Interests
Surgical Robot Embodied Intelligence
Significance
To innovate Embodied-AI-powered next-generation surgical robot copilots to improve surgical efficiency and deliver high-quality patient care in minimally invasive surgery.
-
Ning JiaSouthern University of Science and TechnologyResearch Interests
Elucidating bacterial anti-phage immune mechanisms and developing novel antibacterial strategies
Significance
This research provides new solutions for the prevention and treatment of drug-resistant bacterial infections, holding great promise for human health and the future of medicine.
-
Yizhou JiangFudan UniversityResearch Interests
Molecular Subtyping and Precision Treatment of Triple-Negative Breast Cancer
Significance
Our study aims to develop more effective treatment strategies for triple-negative breast cancer, the most aggressive breast cancer subtype, paving the way for patients to live longer and better lives.
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Chaoyang SunHuazhong University of Science and TechnologyResearch Interests
New approaches to fertility-sparing treatment for cervical cancer
Significance
This research aims to develop novel biotherapeutic regimens for cervical cancer, establish a "chemotherapy-free" treatment strategy, and achieve a new therapeutic model characterized by high efficacy and low toxicity, thereby creating the possibility of fertility preservation for young patients.
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Chen WangSuzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical CollegeResearch Interests
Circadian Control of Immune Response
Significance
We aim to understand how the “circadian clock” influences the immune system, uncovering new mechanisms of disease, and to explore how to leverage the “biological clock” to improve the immunotherapy.
-
Daichao XuShanghai Institute of Organic Chemistry, Chinese Academy of SciencesResearch Interests
Cell death mechanisms and their roles in human diseases.
Significance
This research aims to investigate why cells die, elucidate the underlying processes of cell death, and develop strategies to treat diseases caused by aberrant cell death. The ultimate goal is to promote human health and longevity.
-
Yilun YingNanjing UniversityResearch Interests
Nanopore-based single-molecule protein sequencing and its applications
Significance
Nanopore single-molecule protein sequencing directly detects amino acid sequence variations from individual protein molecules, functioning as a molecular “barcode reader.” This technology will enable the development of next-generation sequencing instruments and drive advances in diagnostics and personalized medicine.
-
Shengtao ZhouSichuan UniversityResearch Interests
The mechanisms for tumor therapy resistance and related translational research
Significance
Given the context that cancer patients develop primary and acquired resistance to standard of care regimens, we aim to decipher the molecular mechanisms underlying distinct treatment responses, from both tumor microenvironmental and macroenvironmental perspective, and design prospective clinical trials to translate our findings for patient survival benefit.
-
Youwen ZhuangShanghai Jiao Tong UniversityResearch Interests
Molecular Pharmacology of Receptors and Drug Design
Significance
Exploring precise regulatory mechanisms of opioid receptor pharmacology to design and develop novel opioid lead compounds with high analgesic efficacy and low toxicity, thereby advancing new clinical approaches for pain management.
-
Yuan ZongChina Agricultural UniversityResearch Interests
Development and innovative applications of plant chromosome editing technologies
Significance
This project is dedicated to developing a new generation of precise and efficient "gene editors" to achieve the remodeling of plant genomes from the base pair to the chromosome level. Leveraging this technology, we can design crop traits as easily as tailoring garments, rapidly cultivating high-yield, high-quality, and disease-resistant "super crops," and even creating entirely new species. This breakthrough will provide core technological support for national food security, heralding a new era of intelligent and customized agricultural breeding.
Energy, Environment and Climate Change
-
Lin ChangPeking UniversityResearch Interests
Low-power, high-performance photonic chips
Significance
Chips are the "brains" of mobile phones, computers, and robots. The project has developed a technology that allows light to "run" on chips—photonic chips. This enables the "brain" to "think" at the speed of light, making machines smarter, computers more portable, and mobile phones more energy-efficient.
-
Xiao ChenTsinghua UniversityResearch Interests
Characterization of Nanoconfined Catalytic Structures
Significance
Advancing technological progress and industrial transformation and upgrading in key areas such as the resource utilization of CO₂, efficient production of renewable energy, and synthesis of high-value-added chemicals.
-
Yuanzhi JiangNankai UniversityResearch Interests
Energy Conversion Materials and Devices/Hybrid Semiconductors for Polarized Optoelectronics
Significance
This project aims to exploit a new class of hybrid semiconductor devices capable of generating and manipulating light with varied polarization states. This capability is critical for next-generation applications, including high-fidelity AR/VR displays, contrast-enhanced medical imaging, and secure optical communications.
-
Feng JiaoDalian Institute of Chemical Physics, Chinese Academy of SciencesResearch Interests
C1 Molecule Heterogeneous Catalytic Conversion
Significance
Developing new catalyst systems and reaction pathways to enhance carbon atom utilization efficiency in coal-based syngas conversion by leveraging green hydrogen resources, thereby reducing carbon dioxide emissions. These advancements are expected to enable more clean and efficient utilization of coal resources to produce value-added chemicals, supporting the achievement of "dual carbon" target.
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Suxin QianXi'an Jiaotong UniversityResearch Interests
Efficient elastocaloric cooling with near-zero carbon emissions
Significance
Elastocaloric cooling is based on caloric effect associated with solid-state phase transitions. The advantages of elastocaloric cooling include zero refrigerant-level emissions, insensitive to gravity, low noise/vibration, and potential high efficiency. R&D in elastocaloric cooling technology will expand the knowledge in refrigeration as well as thermodynamics at large, promoting life-cycle carbon emission reduction in refrigeration equipment in the future.
-
Peng TanUniversity of Science and Technology of ChinaResearch Interests
Intelligent Battery with Integrated Sensing and Analytics
Significance
This refers to the development of a new generation of intelligent batteries which are equipped with built-in high-precision sensors for real-time internal status monitoring and intelligent processors for self-analysis, diagnosis, and prognostics, significantly improving safety and reliability.
-
Fan WuInstitute of Physics, Chinese Academy of SciencesResearch Interests
Key technology of all solid state battery and sulfide solid electrolytes
Significance
All-solid-state batteries use solid electrolytes to replace flammable and explosive liquid electrolytes, which can fundamentally solve safety problems.
-
Yuhao ZhangThe University of Hong KongResearch Interests
Third/fourth generation semiconductors, power electronics
Significance
Third- and fourth-generation power semiconductors can enable more efficient energy conversion in areas such as power grids, data centers, industry, consumer electronics, electric vehicles, and low-altitude spacecraft. They significantly reduce energy losses, thereby supporting the achievement of carbon neutrality.
Medical and Life Sciences
-
Yunlong CaoPeking University
Research Interests
Development of Long-Acting Neutralizing Antibody Nasal Spray for Respiratory Viruses
Significance
To develop a broad-spectrum neutralizing antibody formulation capable of prolonged retention on the nasal mucosa for the long lasting prevention of respiratory viral infections.
-
Yupei ChenSun Yat-sen University
Research Interests
Innovations and Applications in the Metastatic Mechanisms and Precision Treatment Strategies for Nasopharyngeal Carcinoma
Significance
Our findings are like equipping the diagnosis and treatment of nasopharyngeal carcinoma with a “navigation system”: they not only enable more precise identification of patients at high risk of metastasis, but also reveal novel therapeutic targets. Going forward, we will further optimize strategies to enhance efficacy and reduce toxicity in nasopharyngeal carcinoma treatment based on molecular subtyping, artificial intelligence, and other cutting-edge technologies.
-
Qi DouThe Chinese University of Hong Kong
Research Interests
Surgical Robot Embodied Intelligence
Significance
To innovate Embodied-AI-powered next-generation surgical robot copilots to improve surgical efficiency and deliver high-quality patient care in minimally invasive surgery.
-
Ning JiaSouthern University of Science and Technology
Research Interests
Elucidating bacterial anti-phage immune mechanisms and developing novel antibacterial strategies
Significance
This research provides new solutions for the prevention and treatment of drug-resistant bacterial infections, holding great promise for human health and the future of medicine.
-
Yizhou JiangFudan University
Research Interests
Molecular Subtyping and Precision Treatment of Triple-Negative Breast Cancer
Significance
Our study aims to develop more effective treatment strategies for triple-negative breast cancer, the most aggressive breast cancer subtype, paving the way for patients to live longer and better lives.
-
Chaoyang SunHuazhong University of Science and Technology
Research Interests
New approaches to fertility-sparing treatment for cervical cancer
Significance
This research aims to develop novel biotherapeutic regimens for cervical cancer, establish a "chemotherapy-free" treatment strategy, and achieve a new therapeutic model characterized by high efficacy and low toxicity, thereby creating the possibility of fertility preservation for young patients.
-
Chen WangSuzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College
Research Interests
Circadian Control of Immune Response
Significance
We aim to understand how the “circadian clock” influences the immune system, uncovering new mechanisms of disease, and to explore how to leverage the “biological clock” to improve the immunotherapy.
-
Daichao XuShanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Research Interests
Cell death mechanisms and their roles in human diseases.
Significance
This research aims to investigate why cells die, elucidate the underlying processes of cell death, and develop strategies to treat diseases caused by aberrant cell death. The ultimate goal is to promote human health and longevity.
-
Yilun YingNanjing University
Research Interests
Nanopore-based single-molecule protein sequencing and its applications
Significance
Nanopore single-molecule protein sequencing directly detects amino acid sequence variations from individual protein molecules, functioning as a molecular “barcode reader.” This technology will enable the development of next-generation sequencing instruments and drive advances in diagnostics and personalized medicine.
-
Shengtao ZhouSichuan University
Research Interests
The mechanisms for tumor therapy resistance and related translational research
Significance
Given the context that cancer patients develop primary and acquired resistance to standard of care regimens, we aim to decipher the molecular mechanisms underlying distinct treatment responses, from both tumor microenvironmental and macroenvironmental perspective, and design prospective clinical trials to translate our findings for patient survival benefit.
-
Youwen ZhuangShanghai Jiao Tong University
Research Interests
Molecular Pharmacology of Receptors and Drug Design
Significance
Exploring precise regulatory mechanisms of opioid receptor pharmacology to design and develop novel opioid lead compounds with high analgesic efficacy and low toxicity, thereby advancing new clinical approaches for pain management.
-
Yuan ZongChina Agricultural University
Research Interests
Development and innovative applications of plant chromosome editing technologies
Significance
This project is dedicated to developing a new generation of precise and efficient "gene editors" to achieve the remodeling of plant genomes from the base pair to the chromosome level. Leveraging this technology, we can design crop traits as easily as tailoring garments, rapidly cultivating high-yield, high-quality, and disease-resistant "super crops," and even creating entirely new species. This breakthrough will provide core technological support for national food security, heralding a new era of intelligent and customized agricultural breeding.
Energy, Environment and Climate Change
-
Lin ChangPeking University
Research Interests
Low-power, high-performance photonic chips
Significance
Chips are the "brains" of mobile phones, computers, and robots. The project has developed a technology that allows light to "run" on chips—photonic chips. This enables the "brain" to "think" at the speed of light, making machines smarter, computers more portable, and mobile phones more energy-efficient.
-
Xiao ChenTsinghua University
Research Interests
Characterization of Nanoconfined Catalytic Structures
Significance
Advancing technological progress and industrial transformation and upgrading in key areas such as the resource utilization of CO₂, efficient production of renewable energy, and synthesis of high-value-added chemicals.
-
Yuanzhi JiangNankai University
Research Interests
Energy Conversion Materials and Devices/Hybrid Semiconductors for Polarized Optoelectronics
Significance
This project aims to exploit a new class of hybrid semiconductor devices capable of generating and manipulating light with varied polarization states. This capability is critical for next-generation applications, including high-fidelity AR/VR displays, contrast-enhanced medical imaging, and secure optical communications.
-
Feng JiaoDalian Institute of Chemical Physics, Chinese Academy of Sciences
Research Interests
C1 Molecule Heterogeneous Catalytic Conversion
Significance
Developing new catalyst systems and reaction pathways to enhance carbon atom utilization efficiency in coal-based syngas conversion by leveraging green hydrogen resources, thereby reducing carbon dioxide emissions. These advancements are expected to enable more clean and efficient utilization of coal resources to produce value-added chemicals, supporting the achievement of "dual carbon" target.
-
Suxin QianXi'an Jiaotong University
Research Interests
Efficient elastocaloric cooling with near-zero carbon emissions
Significance
Elastocaloric cooling is based on caloric effect associated with solid-state phase transitions. The advantages of elastocaloric cooling include zero refrigerant-level emissions, insensitive to gravity, low noise/vibration, and potential high efficiency. R&D in elastocaloric cooling technology will expand the knowledge in refrigeration as well as thermodynamics at large, promoting life-cycle carbon emission reduction in refrigeration equipment in the future.
-
Peng TanUniversity of Science and Technology of China
Research Interests
Intelligent Battery with Integrated Sensing and Analytics
Significance
This refers to the development of a new generation of intelligent batteries which are equipped with built-in high-precision sensors for real-time internal status monitoring and intelligent processors for self-analysis, diagnosis, and prognostics, significantly improving safety and reliability.
-
Fan WuInstitute of Physics, Chinese Academy of Sciences
Research Interests
Key technology of all solid state battery and sulfide solid electrolytes
Significance
All-solid-state batteries use solid electrolytes to replace flammable and explosive liquid electrolytes, which can fundamentally solve safety problems.
-
Yuhao ZhangThe University of Hong Kong
Research Interests
Third/fourth generation semiconductors, power electronics
Significance
Third- and fourth-generation power semiconductors can enable more efficient energy conversion in areas such as power grids, data centers, industry, consumer electronics, electric vehicles, and low-altitude spacecraft. They significantly reduce energy losses, thereby supporting the achievement of carbon neutrality.